Proteomic Studies of Galectin-3 Expression in Human Thyroid Diseases by Immunodetection

Cancer Genomics - Proteomics

JISNUSON SVASTI³  CHANTRAGAN SRISOMSAP²  PANTIPA SUBHASITANONT²  PHAIBUL PUNYARIT¹ 

[1] epartment of Pathology, Pramongkutklao College of Medicineepartment of Pathology, Pramongkutklao College of Medicineepartment of Pathology, Pramongkutklao College of Medicine;aboratory of Biochemistry, Chulabhorn Research Instituteaboratory of Biochemistry, Chulabhorn Research Instituteaboratory of Biochemistry, Chulabhorn Research Institute;aboratory of Biochemistry, Chulabhorn Research Instituteepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailandaboratory of Biochemistry, Chulabhorn Research Instituteaboratory of Biochemistry, Chulabhorn Research Instituteepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailandepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailandaboratory of Biochemistry, Chulabhorn Research Instituteepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand

关键词: Galectin-3;    thyroid diseases;    proteomics;    immunodetection;    papillary carcinoma;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Galectin-3 expression in thyroid diseases was studied by 1-DE immunoblotting. Expression was markedly elevated in thyroid papillary carcinoma, compared to follicular adenoma, follicular carcinoma or non-neoplastic diseases. Galectin-3 expression was also elevated in malignant cancers of bone, breast, colon, esophagus, larynx, lung and ovary. Four cases of thyroid papillary carcinoma with metastasis gave 2-3 bands on 1-DE immunoblotting. 2-DE immunoblotting of gelectin-3 showed 3 dark spots with MW/pI 32.9/8.29, 31.0/8.40 and 30.0/8.40 and 2 light spots.

【 授权许可】

Unknown