Biomarkers for Sensitivity to Docetaxel and Paclitaxel in Human Tumor Cell Lines In Vitro

Cancer Genomics - Proteomics

DAVID CAMPOS¹  ANTHONY TOLCHER¹  ELZBIETA IZBICKA¹  GILBERT CARRIZALES¹ 

[1] Cancer Therapy and Research Center, The Institute for Drug Development, 14960 Omicron Drive, San Antonio, TX 78245, U.S.A. Cancer Therapy and Research Center, The Institute for Drug Development, 14960 Omicron Drive, San Antonio, TX 78245, U.S.A. Cancer Therapy and Research Center, The Institute for Drug Development, 14960 Omicron Drive, San Antonio, TX 78245, U.S.A.

关键词: Docetaxel;    paclitaxel;    cancer;    biomarker;    Bcl-2;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. Materials and Methods: We compared drug cytotoxicity, effects on β-tubulin isoforms, markers of apoptosis and proteomic profiles in human prostate (LNCaP), lung (SK-MES, MV-522) and breast (MCF-7, MDA-231) cancer cell lines in vitro. Results: Cytotoxicity followed the order SK-MES

【 授权许可】

Unknown