Sirtuin deacylases: a molecular link between metabolism and immunity

Journal of Leukocyte Biology

Nicolas Preyat and²  Oberdan Leo, ²  *¹  Nicolas Preyat¹  Oberdan Leo¹ 

[1] Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, and Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, and Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, and Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, and Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium;Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, and  Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium

关键词: NAD;    SIRT1;    SIRT6;    inflammation;    NAMPT;   

DOI  :  10.1189/jlb.1112557

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Lysine deacetylation by the NAD+-dependent family of sirtuins has been recognized as an important post-translational modification regulating a wide range of cellular processes. These lysine deacetylases have attracted much interest based on their ability to promote survival in response to stress. Sirtuins require NAD+ for their enzymatic activity, suggesting that these enzymes may represent molecular links between cell metabolism and several human disorders, including diabetes and cancer. Inflammation represents a pathological situation with clear connections to metabolism and aging in humans, raising the possibility that sirtuins may also play an important role during a normal and/or a pathological immune response. A growing body of data has confirmed the immunomodulatory properties of sirtuins, although often with contrasting and opposing conclusions. These observations will be summarized herein and the possible strategies that may lead to the development of novel therapeutic approaches to treat inflammation briefly discussed.

【 授权许可】

Unknown