Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Sirtuin deacylases: a molecular link between metabolism and immunity | |
关键词: NAD; SIRT1; SIRT6; inflammation; NAMPT; | |
DOI : 10.1189/jlb.1112557 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
LysinedeacetylationbytheNAD+‐dependentfamilyofsirtuinshasbeenrecognizedasanimportantpost‐translationalmodificationregulatingawiderangeofcellularprocesses.Theselysinedeacetylaseshaveattractedmuchinterestbasedontheirabilitytopromotesurvivalinresponsetostress.SirtuinsrequireNAD+fortheirenzymaticactivity,suggestingthattheseenzymesmayrepresentmolecularlinksbetweencellmetabolismandseveralhumandisorders,includingdiabetesandcancer.Inflammationrepresentsapathologicalsituationwithclearconnectionstometabolismandaginginhumans,raisingthepossibilitythatsirtuinsmayalsoplayanimportantroleduringanormaland/orapathologicalimmuneresponse.Agrowingbodyofdatahasconfirmedtheimmunomodulatorypropertiesofsirtuins,althoughoftenwithcontrastingandopposingconclusions.Theseobservationswillbesummarizedhereinandthepossiblestrategiesthatmayleadtothedevelopmentofnoveltherapeuticapproachestotreatinflammationbrieflydiscussed...
【 授权许可】
CC BY
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