| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Sirtuin deacylases: a molecular link between metabolism and immunity | |
| 关键词: NAD; SIRT1; SIRT6; inflammation; NAMPT; | |
| DOI : 10.1189/jlb.1112557 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
LysinedeacetylationbytheNAD+‐dependentfamilyofsirtuinshasbeenrecognizedasanimportantpost‐translationalmodificationregulatingawiderangeofcellularprocesses.Theselysinedeacetylaseshaveattractedmuchinterestbasedontheirabilitytopromotesurvivalinresponsetostress.SirtuinsrequireNAD+fortheirenzymaticactivity,suggestingthattheseenzymesmayrepresentmolecularlinksbetweencellmetabolismandseveralhumandisorders,includingdiabetesandcancer.Inflammationrepresentsapathologicalsituationwithclearconnectionstometabolismandaginginhumans,raisingthepossibilitythatsirtuinsmayalsoplayanimportantroleduringanormaland/orapathologicalimmuneresponse.Agrowingbodyofdatahasconfirmedtheimmunomodulatorypropertiesofsirtuins,althoughoftenwithcontrastingandopposingconclusions.Theseobservationswillbesummarizedhereinandthepossiblestrategiesthatmayleadtothedevelopmentofnoveltherapeuticapproachestotreatinflammationbrieflydiscussed...
【 授权许可】
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【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043430715ZK.pdf | 700KB |  download |
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