期刊论文详细信息
Journal of Leukocyte Biology
The importance of the macrophage within the human endometrium
Philippa T. K. Saunders and1  Uma Thiruchelvam1  Ian Dransfield1  Hilary O. D. Critchley1 
[1] Medical Research Council Centres for Reproductive Health and  Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom
关键词: menstruation;    matrix metalloproteinases;    repair;    breakdown;   
DOI  :  10.1189/jlb.0712327
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
PDF
【 摘 要 】

The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the latter stages of the menstrual cycle, including menses. We believe the endometrial macrophage is likely to play an important role during the menstrual cycle, especially in the context of tissue degradation (menstruation), which requires regulated repair, regeneration, and phagocytic clearance of endometrial tissue debris to re-establish tissue integrity in preparation for fertility. The phenotype and regulation of the macrophage within the endometrium during the menstrual cycle and interactions with other cell types that constitute the endometrium are currently unknown and are important areas of study. Understanding the many roles of the endometrial macrophage is crucial to our body of knowledge concerning functionality of the endometrium as well as to our understanding of disorders of the menstrual cycle, which have major impacts on the health and well-being of women.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201912010183321ZK.pdf 41KB PDF download
  文献评价指标  
  下载次数:0次 浏览次数:5次