TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

Journal of Leukocyte Biology

Jos W. M. van der Meer¹  Rob J. W. Arts¹  Mihai G. Netea¹  Leo A. B. Joosten¹ 

[1] Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands

关键词: TLR;    NLR;    DAP12;    signaling cascade;    myeloid cells;   

DOI  :  10.1189/jlb.0312145

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

TREM-1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM-1. Because of the absence of signaling motifs, TREM-1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM-1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM-1 influences TLR and NLR pathways are still largely elusive.

【 授权许可】

Unknown