Trauma equals danger—damage control by the immune system

Journal of Leukocyte Biology

James A. Lederer¹  Akinori Osuka¹  Veit M. Stoecklein¹ 

[1] Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USADepartment of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USADepartment of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA

关键词: injury;    inflammation;    macrophages;    T regulatory cells (Tregs);    alarmins;    DAMPs;   

DOI  :  10.1189/jlb.0212072

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Traumatic injuries induce a complex host response that disrupts immune system homeostasis and predisposes patients to opportunistic infections and inflammatory complications. The response to injuries varies considerably by type and severity, as well as by individual variables, such as age, sex, and genetics. These variables make studying the impact of trauma on the immune system challenging. Nevertheless, advances have been made in understanding how injuries influence immune system function as well as the immune cells and pathways involved in regulating the response to injuries. This review provides an overview of current knowledge about how traumatic injuries affect immune system phenotype and function. We discuss the current ideas that traumatic injuries induce a unique type of a response that may be triggered by a combination of endogenous danger signals, including alarmins, DAMPs, self-antigens, and cytokines. Additionally, we review and propose strategies for redirecting injury responses to help restore immune system homeostasis.

【 授权许可】

Unknown