C1q and phagocytosis: the perfect complement to a good meal

Journal of Leukocyte Biology

Mallary C. Greenlee-Wacker and¹  Suzanne S. Bohlson, ²  Manuel D. Galvan² 

[1] Inflammation Program and Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA;Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA;  Department of Microbiology and Immunology, Indiana University School of Medicine“South Bend, South Bend, Indiana, USA;

关键词: macrophage;    apoptosis;    autoimmunity;    mertk;    gas6;    C1q deficiency;   

DOI  :  10.1189/jlb.0212099

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role for C1q in the enhancement of phagocyte function and focus specifically on C1q in apoptotic cell clearance. In addition, we highlight our recent findings demonstrating that C1q elicits a macrophage phenotype that is tailored specifically for clearance of apoptotic cells.

【 授权许可】

Unknown