The human side of influenza

Journal of Leukocyte Biology

Christine M. Oshansky¹  Paul G. Thomas¹ 

[1] Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USADepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USADepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

关键词: influenza;    human;    immune response;   

DOI  :  10.1189/jlb.1011506

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

A clear understanding of immunity in individuals infected with influenza virus is critical for the design of effective vaccination and treatment strategies. Whereas myriad studies have teased apart innate and adaptive immune responses to influenza infection in murine models, much less is known about human immunity as a result of the ethical and technical constraints of human research. Still, these murine studies have provided important insights into the critical correlates of protection and pathogenicity in human infection and helped direct the human studies that have been conducted. Here, we examine and review the current literature on immunity in humans infected with influenza virus, noting evidence offered by select murine studies and suggesting directions in which future research is most warranted.

【 授权许可】

Unknown