Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

Journal of Leukocyte Biology

Stephan Pleschka and⁴  Susanne Herold²  Stephan Ludwig³  Thorsten Wolff¹ 

[1] Division of Influenza/Respiratory Viruses, Robert Koch-Institute, Berlin, Germany University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany;University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany; Institute of Molecular Virology, Center of Molecular Biology of Inflammation, University of Muenster, Muenster, Germany;Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany;

关键词: viral;    replication;    NS1;    PB1-F2;    TRAIL;    ARDS;   

DOI  :  10.1189/jlb.1011530

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.

【 授权许可】

Unknown