期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society
Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
关键词: viral;    replication;    NS1;    PB1‐;    F2;    TRAIL;    ARDS;   
DOI  :  10.1189/jlb.1011530
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
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【 摘 要 】

ProgrammedcelldeathisacrucialcellularresponsefrequentlyobservedinIV‐infectedtissue.Thisarticlereviewsthecurrentknowledgeonthemolecularvirus–hostinteractionsthatinduceapoptosispathwaysinanIV‐infectedcellandthefunctionalimplicationsofthesecellularsignalingeventsonviralpropagationatdistinctstepsduringtheviralreplicationcycle.Furthermore,itsummarizestheroleofIV‐inducedapoptosispathwaysinequilibratingthehostˈsantiviralimmuneresponsebetweeneffectiveviralclearanceanddevelopmentofsevereapoptoticlunginjury...

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