Lung dendritic cells at the innate-adaptive immune interface

Journal of Leukocyte Biology

Matthew J. Fenton and³  Richard T. Sawyer³  David W. H. Riches, –²  Tracy Voss Condon¹ 

[1] Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA; Departments of  ImmunologyProgram in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA; Departments of  Immunology and Pharmacology and –Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA;Asthma Allergy and Inflammation Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA;

关键词: asthma;    alveolar macrophage;    antigen processing;   

DOI  :  10.1189/jlb.0311134

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

This review updates the basic biology of lung DCs and their functions. Lung DCs have taken center stage as cellular therapeutic targets in new vaccine strategies for the treatment of diverse human disorders, including asthma, allergic lung inflammation, lung cancer, and infectious lung disease. The anatomical distribution of lung DCs, as well as the division of labor between their subsets, aids their ability to recognize and endocytose foreign substances and to process antigens. DCs can induce tolerance in or activate naïve T cells, making lung DCs well-suited to their role as lung sentinels. Lung DCs serve as a functional signaling/sensing unit to maintain lung homeostasis and orchestrate host responses to benign and harmful foreign substances.

【 授权许可】

Unknown