期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Lung dendritic cells at the innate‐adaptive immune interface | |
| 关键词: asthma; alveolar macrophage; antigen processing; | |
| DOI : 10.1189/jlb.0311134 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ThisreviewupdatesthebasicbiologyoflungDCsandtheirfunctions.LungDCshavetakencenterstageascellulartherapeutictargetsinnewvaccinestrategiesforthetreatmentofdiversehumandisorders,includingasthma,allergiclunginflammation,lungcancer,andinfectiouslungdisease.TheanatomicaldistributionoflungDCs,aswellasthedivisionoflaborbetweentheirsubsets,aidstheirabilitytorecognizeandendocytoseforeignsubstancesandtoprocessantigens.DCscaninducetoleranceinoractivatenaïveTcells,makinglungDCswell‐suitedtotheirroleaslungsentinels.LungDCsserveasafunctionalsignaling/sensingunittomaintainlunghomeostasisandorchestratehostresponsestobenignandharmfulforeignsubstances...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904040475438ZK.pdf | 881KB |  download |
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