The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

Journal of Leukocyte Biology

Duccio Cavalieri³  Frank L. van de Veerdonk¹  Bart Jan Kullberg¹  Leo A. B. Joosten¹  Sanne Smeekens¹  Liliane Mukaremera²  Lisa Rizzetto³  Jos W. M. van der Meer¹  Megan Lenardon²  Monique Stoffels¹  Mihai G. Netea¹  Shih-Chin Cheng¹  Theo Plantinga¹  Neil A. R. Gow  and²  Kanya Preechasuth²  Thirumala Devi Kanneganti⁴ 

[1] Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, United Kingdom;Department of Preclinic and Clinic Pharmacology, University of Florence, Florence, Italy;Department of Immunology, St. Jude Children²s Research Hospital, Memphis, Tennessee, USA Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;

关键词: Candida;    colonization;    invasion;    IL-1β;    IL-17;   

DOI  :  10.1189/jlb.1210702

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1β in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans.

【 授权许可】

Unknown