Phagosome dynamics during phagocytosis by neutrophils

Journal of Leukocyte Biology

Hans Tapper¹  Pontus Nordenfelt¹ 

[1] Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden

关键词: membrane traffic;    pH;    granules;    NADPH oxidase;    Fc receptors;   

DOI  :  10.1189/jlb.0810457

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation.

【 授权许可】

Unknown