Hijacked phagosomes and leukocyte activation: an intimate relationship

Journal of Leukocyte Biology

Abdoulaye Oury Barry¹  Eric Ghigo¹  Jean-Louis Mege¹ 

[1] URMITE CNRS UMR 6236-IRD 3R198, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, FranceURMITE CNRS UMR 6236-IRD 3R198, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, FranceURMITE CNRS UMR 6236-IRD 3R198, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, France

关键词: cytokines;    phagolysosomes;    endosomes;    bacteria;   

DOI  :  10.1189/jlb.0510270

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Intracellular pathogens have developed different strategies to survive within host cells. For example, these pathogens might interfere with the biogenesis of phagolysosomes, thereby forming replicative vacuoles. Although the complex mechanisms used by pathogens to hijack the biogenesis of phagolysosomes have been elucidated in naive leukocytes, the role of leukocyte activation in this process has not yet been investigated. Leukocytes are known to be activated by cytokines, and several reports have demonstrated that several cytokines modulate the endocytic pathway and thereby, affect phagosome biogenesis. These observations provide molecular evidence that endocytosis can be regulated by the immune environment. In this review, we highlight the effect of leukocyte activation by cytokines on the endocytic pathway and on phagosome biogenesis. We briefly describe the mechanism of phagolysosome formation before focusing on the strategies used by two bacterial pathogens, Coxiella burnetii and Mycobacterium tuberculosis, to hijack phagolysosome biogenesis. Finally, we emphasize the effect of leukocyte activation on the endocytic pathway and on phagolysosome formation, which has not been highlighted to date.

【 授权许可】

Unknown