| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Hijacked phagosomes and leukocyte activation: an intimate relationship | |
| 关键词: cytokines; phagolysosomes; endosomes; bacteria; | |
| DOI : 10.1189/jlb.0510270 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Intracellularpathogenshavedevelopeddifferentstrategiestosurvivewithinhostcells.Forexample,thesepathogensmightinterferewiththebiogenesisofphagolysosomes,therebyformingreplicativevacuoles.Althoughthecomplexmechanismsusedbypathogenstohijackthebiogenesisofphagolysosomeshavebeenelucidatedinnaiveleukocytes,theroleofleukocyteactivationinthisprocesshasnotyetbeeninvestigated.Leukocytesareknowntobeactivatedbycytokines,andseveralreportshavedemonstratedthatseveralcytokinesmodulatetheendocyticpathwayandthereby,affectphagosomebiogenesis.Theseobservationsprovidemolecularevidencethatendocytosiscanberegulatedbytheimmuneenvironment.Inthisreview,wehighlighttheeffectofleukocyteactivationbycytokinesontheendocyticpathwayandonphagosomebiogenesis.Webrieflydescribethemechanismofphagolysosomeformationbeforefocusingonthestrategiesusedbytwobacterialpathogens,CoxiellaburnetiiandMycobacteriumtuberculosis,tohijackphagolysosomebiogenesis.Finally,weemphasizetheeffectofleukocyteactivationontheendocyticpathwayandonphagolysosomeformation,whichhasnotbeenhighlightedtodate...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904046583332ZK.pdf | 398KB |  download |
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