Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury

Journal of Leukocyte Biology

Ann M. McKenna¹  James A. Lederer¹  Christopher G. Stallwood¹  Goro Tajima¹  John A. Mannick¹  Fionnuala O'Leary¹  Adam J. Delisle¹  Malcolm P. MacConmara¹ 

[1] Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

关键词: inflammation;    immunization;    danger-associated molecular patterns (DAMPs);    SIRS;    CARS;   

DOI  :  10.1189/jlb.0210082

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Injury initiates local and systemic host responses and is known to increase CD4 Treg activity in mice and humans. This study uses a TCR transgenic T cell adoptive transfer approach and in vivo Treg depletion to determine specifically the in vivo influence of Tregs on antigen-driven CD4 T cell reactivity following burn injury in mice. We report here that injury in the absence of recipient and donor Tregs promotes high antigen-driven CD4 T cell expansion and increases the level of CD4 T cell reactivity. In contrast, CD4 T cell expansion and reactivity were suppressed significantly in injured Treg-replete mice. In additional experiments, we found that APCs prepared from burn- or sham-injured, Treg-depleted mice displayed significantly higher antigen-presenting activity than APCs prepared from normal mice, suggesting that Tregs may suppress injury responses by controlling the intensity of APC activity. Taken together, these findings demonstrate that Tregs can actively control the in vivo expansion and reactivity of antigen-stimulated, naïve CD4 T cells following severe injury.

【 授权许可】

Unknown