Regulatory T cells suppress antigen‐driven CD4 T cell reactivity following injury

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: inflammation;    immunization;    danger‐;    associated molecular patterns (DAMPs);    SIRS;    CARS;   

DOI  :  10.1189/jlb.0210082

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

InjuryinitiateslocalandsystemichostresponsesandisknowntoincreaseCD4Tregactivityinmiceandhumans.ThisstudyusesaTCRtransgenicTcelladoptivetransferapproachandinvivoTregdepletiontodeterminespecificallytheinvivoinfluenceofTregsonantigen‐drivenCD4Tcellreactivityfollowingburninjuryinmice.WereportherethatinjuryintheabsenceofrecipientanddonorTregspromoteshighantigen‐drivenCD4TcellexpansionandincreasesthelevelofCD4Tcellreactivity.Incontrast,CD4TcellexpansionandreactivityweresuppressedsignificantlyininjuredTreg‐repletemice.Inadditionalexperiments,wefoundthatAPCspreparedfromburn‐orsham‐injured,Treg‐depletedmicedisplayedsignificantlyhigherantigen‐presentingactivitythanAPCspreparedfromnormalmice,suggestingthatTregsmaysuppressinjuryresponsesbycontrollingtheintensityofAPCactivity.Takentogether,thesefindingsdemonstratethatTregscanactivelycontroltheinvivoexpansionandreactivityofantigen‐stimulated,naïveCD4Tcellsfollowingsevereinjury...

【 授权许可】

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