FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling

Journal of Leukocyte Biology

Anne Montfort²  Pascal G. P. Martin³  Bruno Ségui ¹  Hervé Benoist  and¹  Thierry Levade² 

[1] U858 INSERM, Département Cancer, Toulouse, Cedex 4, France;  IFR50, Institut de médecine moléculaire de Rangueil, Toulouse, Cedex 4, France; Université Paul Sabatier (Toulouse III), Faculté des sciences pharmaceutiques, service d'immunologie, Toulouse, FranceU858 INSERM, Département Cancer, Toulouse, Cedex 4, France;  IFR50, Institut de médecine moléculaire de Rangueil, Toulouse, Cedex 4, France;Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse, France;

关键词: NSMAF;    ceramide;    apoptosis;    inflammation;    immune response;   

DOI  :  10.1189/jlb.0410188

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

TNF-α is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-α triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-α rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-α-induced cell signaling and biological responses is discussed.

【 授权许可】

Unknown