Hibernation: the immune system at rest?

Journal of Leukocyte Biology

Frans G. M. Kroese²  Hjalmar R. Bouma¹  Hannah V. Carey  and³ 

[1] Departments of Clinical Pharmacology and Cell Biology/Immunology Section and Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands;Cell Biology/Immunology Section and Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA Cell Biology/Immunology Section and Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands;

关键词: torpor;    immunosuppression;    white nose syndrome;    metabolism;    hypothermia;   

DOI  :  10.1189/jlb.0310174

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Mammalian hibernation consists of torpor phases when metabolism is severely depressed, and Tb can reach as low as approximately –2°C, interrupted by euthermic arousal phases. Hibernation affects the function of the innate and the adaptive immune systems. Torpor drastically reduces numbers of all types of circulating leukocytes. In addition, other changes have been noted, such as lower complement levels, diminished response to LPS, phagocytotic capacity, cytokine production, lymphocyte proliferation, and antibody production. Hibernation may therefore increase infection risk, as illustrated by the currently emerging WNS in hibernating bats. Unraveling the pathways that result in reduced immune function during hibernation will enhance our understanding of immunologic responses during extreme physiological changes in mammals.

【 授权许可】

Unknown