CSF-1, IGF-1, and the control of postnatal growth and development

Journal of Leukocyte Biology

Deborah J. Gow¹  David P. Sester¹  David A. Hume¹ 

[1] The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, United KingdomThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, United KingdomThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom

关键词: macrophage;    hormone;    extrahepatic;    somatomedin hypothesis;   

DOI  :  10.1189/jlb.0310158

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic growth and organogenesis. We propose that macrophages are the major extrahepatic source of IGF-1 and that a surge of CSF-1 production contributes to the control of postnatal growth and organ maturation. Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis.

【 授权许可】

Unknown