期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| CSF‐1, IGF‐1, and the control of postnatal growth and development | |
| 关键词: macrophage; hormone; extrahepatic; somatomedin hypothesis; | |
| DOI : 10.1189/jlb.0310158 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
GrowthhormonecontrolssomaticgrowthinmammalsbyregulatingtheproductionofIGF‐1,whichispredominantlymadebytheliver.ThedevelopmentofcellswithintheMPSiscontrolledbythelineage‐specificgrowthfactorM‐CSF(CSF‐1).Inthisreview,wesummarizetheroleofCSF‐1‐dependentmacrophagesinsomaticgrowthandorganogenesis.WeproposethatmacrophagesarethemajorextrahepaticsourceofIGF‐1andthatasurgeofCSF‐1productioncontributestothecontrolofpostnatalgrowthandorganmaturation.Accordingly,CSF‐1maybeconsideredapartoftheGH/IGF‐1axis...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904045945253ZK.pdf | 307KB |  download |
878987797
028-85220240
