CCR7 regulates lymphocyte egress and recirculation through body cavities

Journal of Leukocyte Biology

Uta E. Höpken¹  Susann Winter¹  Kerstin Krüger¹  Martin Lipp¹  Ariel H. Achtman¹ 

[1] Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, MDC, Berlin, GermanyDepartment of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, MDC, Berlin, GermanyDepartment of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, MDC, Berlin, Germany

关键词: chemokine receptor;    peritoneal cavity;    homeostatic;    recirculation;    exit signal;   

DOI  :  10.1189/jlb.0709505

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

T and B lymphocytes recirculate among blood, lymph, and extralymphoid tissues to ensure immune surveillance and the establishment of self-tolerance. The underlying mechanisms regulating homeostatic lymphocyte recirculation through body cavities are not fully understood. Here, we demonstrate that the homeostatic chemokine receptor CCR7 regulates homeostatic recirculation of lymphocytes through body cavities. CCR7 deficiency results in massive accumulation of CD4+ and CD8+ T cells and B-2 B cells in the peritoneal and pleural cavities. The increase in B-2 B and T lymphocytes is not associated with an altered maturation and/or activation status of these cells. Mechanistically, an increase in peritoneal lymphocyte numbers is caused by impaired egress of CCR7-deficient lymphocytes from body cavities. These results establish that CCR7 plays a crucial role in lymphocyte exit from the PerC.

【 授权许可】

Unknown