The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma

Journal of Leukocyte Biology

Michael S. McGrath¹  Leanne C. Huysentruyt¹ 

[1] Department of Medicine, Hematology and Oncology, University of California, San Francisco, California, USADepartment of Medicine, Hematology and Oncology, University of California, San Francisco, California, USADepartment of Medicine, Hematology and Oncology, University of California, San Francisco, California, USA

关键词: HIV;    reservoir;    metastasis;    cancer;   

DOI  :  10.1189/jlb.0809564

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Despite HAART, patients infected with HIV develop NHL at a significantly higher level than the noninfected population. The primary difference between lymphoma in non-HIV-infected individuals and those with ARL is that ARL is consistently high-grade and metastatic. The emergence of ARL is associated with the presence of macrophage viral reservoirs, similar to what has been observed for HAD. HIV-infected macrophages, as seen by histology and HIV p24 staining, are present in approximately half of ARLs. Macrophage reservoirs recruit additional immune cells, including monocytes/macrophages, through the release of chemoattractants. Additionally, TAM are known to promote tumor progression for most cancer types, including lymphomas. This review will highlight and discuss the role of macrophage viral reservoirs in the development and progression of ARLs and hopefully, shed light on this new and interesting field.

【 授权许可】

Unknown