| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The role of macrophages in the development and progression of AIDS‐related non‐Hodgkin lymphoma | |
| 关键词: HIV; reservoir; metastasis; cancer; | |
| DOI : 10.1189/jlb.0809564 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
DespiteHAART,patientsinfectedwithHIVdevelopNHLatasignificantlyhigherlevelthanthenoninfectedpopulation.Theprimarydifferencebetweenlymphomainnon‐HIV‐infectedindividualsandthosewithARListhatARLisconsistentlyhigh‐gradeandmetastatic.TheemergenceofARLisassociatedwiththepresenceofmacrophageviralreservoirs,similartowhathasbeenobservedforHAD.HIV‐infectedmacrophages,asseenbyhistologyandHIVp24staining,arepresentinapproximatelyhalfofARLs.Macrophagereservoirsrecruitadditionalimmunecells,includingmonocytes/macrophages,throughthereleaseofchemoattractants.Additionally,TAMareknowntopromotetumorprogressionformostcancertypes,includinglymphomas.ThisreviewwillhighlightanddiscusstheroleofmacrophageviralreservoirsinthedevelopmentandprogressionofARLsandhopefully,shedlightonthisnewandinterestingfield...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904046760744ZK.pdf | 1026KB |  download |
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