The disconnect between animal models of sepsis and human sepsis

Journal of Leukocyte Biology

Daniel Rittirsch¹  L. Marco Hoesel¹  Peter A. Ward¹ 

[1] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

关键词: cecal ligation and puncture;    lipopolysaccharide;    rodents;   

DOI  :  10.1189/jlb.0806542

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy in septic humans. We describe the shortcomings of the animal models and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsis.

【 授权许可】

Unknown