Cellular reprogramming by gram-positive bacterial components: a review

Journal of Leukocyte Biology

Julliette M. Buckley¹  H. Paul Redmond¹  Jiang Huai Wang¹ 

[1] Department of Academic Surgery, Cork University Hospital, National University of Ireland (NUI)/University College Cork (UCC), Wilton, Cork, Ireland Department of Academic Surgery, Cork University Hospital, National University of Ireland (NUI)/University College Cork (UCC), Wilton, Cork, Ireland Department of Academic Surgery, Cork University Hospital, National University of Ireland (NUI)/University College Cork (UCC), Wilton, Cork, Ireland

关键词: lipoprotein;    lipopolysaccharide;    tolerance;    cross-tolerance;    TLR signaling;   

DOI  :  10.1189/jlb.0506312

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

LPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.

【 授权许可】

Unknown