LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM

Journal of Leukocyte Biology

Byungsuk Kwon¹  Byung-Sam Kim¹  Sang-Min Park¹  Byoung S. Kwon³  Suck-Young Choe²  Seong-A Ju¹  Sang-Chul Lee¹  Sook-Kyoung Heo¹ 

[1] Immunomodulation Research Center and Immunomodulation Research Center and Immunomodulation Research Center and;Department of Food Science and Nutrition, University of Ulsan, Korea; and Department of Food Science and Nutrition, University of Ulsan, Korea; and Department of Food Science and Nutrition, University of Ulsan, Korea; and;Immunomodulation Research Center and Louisiana State University Eye Center, New Orleans Immunomodulation Research Center and Immunomodulation Research Center and Louisiana State University Eye Center, New Orleans Louisiana State University Eye Center, New Orleans Immunomodulation Research Center and Louisiana State University Eye Center, New Orleans

关键词: innate immunity;    inflammatory response;   

DOI  :  10.1189/jlb.1104694

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Human monocytes and neutrophils play major roles in clearing bacteria from human blood and tissues. We found that the herpes virus entry mediator (HVEM) was highly expressed in monocytes and neutrophils, and its interaction with “homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM/tumor necrosis factor (TNF)-related 2” (LIGHT) enhanced bactericidal activity against Listeria monocytogenes and Staphylococcus aureus. The LIGHT-HVEM interaction increased levels of phagocytosis, interleukin (IL)-8, TNF-α, nitric oxide (NO), and reactive oxygen species (ROS) in monocytes and neutrophils. Anti-HVEM monoclonal antibody was able to block LIGHT-induced bactericidal activity, cytokine production (IL-8 and TNF-α), and ROS generation. Moreover, inhibition of ROS and NO production blocked LIGHT-induced bactericidal activity. Our results indicate that the LIGHT/HVEM interaction in monocytes and neutrophils contributes to antibacterial activity.

【 授权许可】

Unknown