Comparison of Cystatin C and β-Trace Protein Versus 99mTc-DTPA Plasma Sampling in Determining Glomerular Filtration Rate in Chronic Renal Disease

Journal of Nuclear Medicine Technology

Fatih Davran¹  Selen Korkmaz¹  Serkan Demirelli¹  Halide Akbas¹  Firat Gungor¹  Funda Aydin¹  Ali Ozan Oner¹  Gultekin Suleymanlar¹  Evrim Surer Budak¹ 

关键词: glomerular filtration rate;    cystatin C;    beta trace protein;   

DOI  :  10.2967/jnmt.115.154799

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Glomerular filtration rate (GFR) is the best indicator of renal function. The gold standard for GFR measurement is inulin clearance. However, its measurement is inconvenient, time-consuming, and costly. Thus, in both scientific studies and routine clinical practice nuclear medicine methods (99mTc-diethylenetriaminepentaacetic acid [99mTc-DTPA] and 51Cr-ethylenediaminetetraacetic acid [51Cr-EDTA]) are preferred, and they correlate strongly with inulin clearance. In addition, cystatin C and β-trace protein have also recently been used for this purpose. In the literature, however, data are limited about the clinical value of cystatin C and β-trace protein in GFR measurement in chronic renal disease (CRD), and the results have been inconclusive. In this study, we aimed to determine the efficiency of cystatin C and β-trace protein in the determination of GFR in CRD patients. Methods: Eighty-four patients with CRD were included in the study (59 men and 25 women; age range, 21–88 y; mean age, 61 y). GFR was calculated using the gold-standard 99mTc-DTPA 2-sample plasma sampling method (TPSM) and 2 alternative methods: a formula using cystatin C and a formula using β-trace protein. The correlation between TPSM and the cystatin C and β-trace protein methods was assessed, and Bland–Altman analysis was used to graph scatterplots of the differences at a confidence interval of 95% (mean difference ± 1.96 SDs). Results: GFRs calculated using both alternative methods correlated strongly with those calculated using the gold standard. However, the correlation was stronger for the cystatin C method than for the β-trace protein method, and neither method produced reliably consistent GFRs. Conclusion: This study demonstrated that cystatin C and β-trace protein do not reflect GFR with sufficient accuracy.

【 授权许可】

Unknown