No Impact of the Analytical Method Used for Determining Cystatin C on Estimating Glomerular Filtration Rate in Children

Frontiers in Pediatrics

Martin Alberer¹ 

关键词: cystatin C;    creatinine;    glomerular filtration rate;    creatinine clearance;    glomerular filtration rate formulas;   

DOI  :  10.3389/fped.2017.00066

学科分类：儿科学

来源: Frontiers

【 摘 要 】

BackgroundMeasurement of inulin clearance is considered to be the gold standard for determining kidney function in children, but this method is time consuming and expensive. The glomerular filtration rate (GFR) is on the other hand easier to calculate by using various creatinine- and/or cystatin C (Cys C)-based formulas. However, for the determination of serum creatinine (Scr) and Cys C, different and non-interchangeable analytical methods exist. Given the fact that different analytical methods for the determination of creatinine and Cys C were used in order to validate existing GFR formulas, clinicians should be aware of the type used in their local laboratory. In this study, we compared GFR results calculated on the basis of different GFR formulas and either used Scr and Cys C values as determined by the analytical method originally employed for validation or values obtained by an alternative analytical method to evaluate any possible effects on the performance.

【 授权许可】

CC BY