Measuring Metabolic Function with PET: Technical Considerations

Journal of Nuclear Medicine Technology

Chin-Tu Chen¹  Nicholas J. Yasillo¹  Terry F. Brown¹  John T. Metz¹  Malcolm D. Cooper¹  Jason Chou¹ 

[1] Franklin McLean Memorial Research Institute, Department of Radiology, The University of Chicago, Chicago, Illinois Franklin McLean Memorial Research Institute, Department of Radiology, The University of Chicago, Chicago, Illinois Franklin McLean Memorial Research Institute, Department of Radiology, The University of Chicago, Chicago, Illinois

关键词: positron emission tomography;    quality control;    fluorine-18-FDG;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective: The purpose of this study was to determine the magnitude of methodologic errors when PET is used for the quantitative measurement of regional cerebral glucose metabolism (rCMRglu).Methods: Performance of the analytic tests, which are the variables in the quantitative measurement of rCMRglu with PET, was evaluated.Results: For the scanner we evaluated, failure to perform daily calibration factor calculations was the single largest source of error. In addition, any variation in the accuracy or precision of patient plasma sample pipetting or plasma glucose level determinations, will result in corresponding changes in rCMRglu.Conclusions: Quantitative measurement of rCMRglu with PET requires close attention to laboratory skills, especially proper operation and maintenance of pipettes.

【 授权许可】

Unknown