A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

PLOS Pathogens

Isabelle Schuffenecker¹  Philippe Desprès¹  Olivier Disson¹  Florence Guivel-Benhassine¹  Fernando Arenzana-Seisdedos¹  Madly Brigitte¹  Marc Lecuit¹  Alain Michault¹  Yasmina Touret¹  Clémentine Schilte¹  Georges Barau¹  Matthew L Albert¹  Nadège Cayet¹  Thérèse Couderc¹  Fabrice Chrétien¹ 

关键词: Chikungunya infection;    Mouse models;    Fibroblasts;    Joints (anatomy);    Viral tropism;    Central nervous system;    Chikungunya virus;    Animal models of infection;   

DOI  :  10.1371/journal.ppat.0040029

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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