Impact of the IL-18 gene polymorphism in response to antiviral therapy in chronic HCV genotype 4 patients

Revista da Sociedade Brasileira de Medicina Tropical

Mandour, Mohamed¹  Kishk, Rania¹  Suez Canal University, Ismailia, Egypt¹  Ahmed, Eman¹  Nemr, Nader¹ 

关键词: IL-18;    Sustained virological response;    HCV genotype 4;    Gene polymorphism;   

DOI  :  10.1590/0037-8682-0024-2014

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

IntroductionInterleukin (IL)-18 is a well-known major proinflammatory cytokine with broad biological effects. The major immunomodulatory functions of IL-18 include enhancing T cell and natural killer cell cytotoxicity. Serum levels of this cytokine were shown to increase in chronic hepatitis C patients compared to non-infected healthy people. An association between IL-18 gene promoter polymorphisms and pegylated interferon (PEG-IFN) and ribavirin treatment outcomes has been reported for individuals with chronic hepatitis C virus genotype 1 (HCV-1). In this study, HCV genotype 4 (HCV-4) patients were assessed for IL-18 gene polymorphisms and treatment outcomes or severity of liver disease because data concerning the impact of IL-18 gene polymorphisms on patients with HCV-4 infections are limited.

【 授权许可】

Unknown