Efficacy of voriconazole in experimental rat paracoccidioidomycosis

Revista da Sociedade Brasileira de Medicina Tropical

Universidade de São Paulo, Ribeirão Preto, Brazil¹  Granzoto, Daniela Silva¹  Martinez, Roberto¹  Vitali, Lúcia Helena¹ 

关键词: Paracoccidioidomycosis;    Paracoccidioides brasiliensis;    Voriconazole;    Itraconazole;    Fluconazole;    Sulfamethoxazole-trimethoprim;   

DOI  :  10.1590/0037-868216432013

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients infected with this fungus.In the present study the antifungal activity of voriconazole and of other drugs was compared in a rat model of paracoccidioidomycosis.

【 授权许可】

Unknown