Hepatitis D virus infection in the Western Brazilian Amazon - far from a vanishing disease

Revista da Sociedade Brasileira de Medicina Tropical

Leão, Jorge Roberto Di Tommaso¹  Borges, Fabiane Giovanella¹  Braga, Wornei Silva Miranda¹  Fundação de Medicina Tropical, Manaus¹  Martinho, Ana Cristina de Souza¹  Azevedo, Eliete Pereira de¹  Rodrigues, Ivo Seixas¹  Castilho, Márcia da Costa¹  Paraná, Raymundo¹  Universidade Federal da Bahia, Salvador¹  Barros Júnior, Gildo Maia de¹ 

关键词: Hepatitis D virus;    Viral diseases;    Epidemiology;   

DOI  :  10.1590/S0037-86822012000600007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: A decline in hepatitis D virus (HDV) occurrence was described in Europe and Asia. We estimated HDV prevalence in the Brazilian Amazon following hepatitis B vaccination.METHODS: This is a cross-sectional survey of HDV measured by total antibodies to HDV (anti-HD T).RESULTS: HDV prevalence was 41.9% whiting HBsAg carries and was associated with age (PR = 1.96; 95% CI 1.12-3.42; p = 0.01), hepatitis B virus (HBV) infection (PR = 4.38; 95% CI 3.12-6.13; p < 0.001), and clinical hepatitis (PR =1.44; 95% CI 1.03-2.00; p = 0.03). Risk factors were related to HDV biology, clinical or demographic aspects such as underlying HBV infection, clinical hepatitis and age.CONCLUSIONS: Our study demonstrated that HDV infection continues to be an important health issue in the Brazilian Amazon and that the implementation of the HBV vaccination in rural Lábrea had little or no impact on the spread of HDV. This shows that HDV has not yet disappeared from HBV hyperendemic areas and reminding that it is far from being a vanishing disease in the Amazon basin.

【 授权许可】

Unknown