Evaluation of laboratory markers of progression of HIV disease to death

Revista da Sociedade Brasileira de Medicina Tropical

Nascimento, Maria do Desterro Soares Brandão¹  Centro Universitário do Maranhão, São Luis¹  Oliveira, Rodrigo Artur Souza de¹  Diniz Neto, João Arnaud¹  Binda Júnior, José Roberto¹  Rabelo, Érica Milena Fernandes¹  Viana, Graça Maria de Castro¹  Santos Júnior, Onildo Martins¹  Ferreira, Aila de Menezes¹  Galvão, Carolina de Souza¹  Santos, Alessandro Carvalho dos¹  Universidade Estadual do Maranhão, Caxias¹  Universidade Federal do Maranhão, São Luis¹ 

关键词: Risk factors;    Prognosis;    HIV/AIDS;   

DOI  :  10.1590/S0037-86822011005000062

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients.METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis.RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed.CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

【 授权许可】

Unknown