期刊论文详细信息
Revista da Sociedade Brasileira de Medicina Tropical
Apical lesions in Chagas' heart disease patients: an autopsy study
Carneiro, Fernanda1  Favoritto, Priscila1  Gurgel, Cristina Brandt Friedrich Martin1  Coutinho, Elaine1  Pontifícia Universidade Católica, Campinas1  Ferreira, Maria Cristina Furian1  Mendes, Clayde Regina1 
关键词: Apical lesion;    Chagas' myocardiopathy;    Autopsy;    Heart aneurysm;   
DOI  :  10.1590/S0037-86822010000600022
学科分类:农业科学(综合)
来源: Sociedade Brasileira de Medicina Tropical
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【 摘 要 】

INTRODUCTION: The presence of an apical ventricular lesion increases the risk of intracardiac thrombosis and thromboembolic phenomena. The study evaluated the incidence of apical lesions and intracardiac thrombosis in Chagas' heart disease patients at autopsy.METHODS: A retrospective review of autopsies of Chagas' heart disease patients was conducted. Statistical analysis included comparison of clinical variables and autopsy findings between two groups: group A (apical lesions) and group B (no apical lesions).RESULTS: A total of 51 cases of Chagas' disease patients were studied: 25 in group A (mean age 53 years-old; 64% male) and 26 in group B. Apical lesions were verified in the left ventricle in 80% of cases. The prevalent clinical subtype in both groups was myopathic, but significant cardiac arrhythmia was present in 57.9% of patients in group A, while 76.9% in group B did not present arrhythmias. Mean heart weight was 500.9g in group A and 408.4g in group B. The presence of thrombosis occurred in 60% of group A with 8 (53.3%) thrombi occurring in the apical lesion.CONCLUSIONS: The myopathic subtype was the most common clinical form in group A and the mean heart weight was statistically higher in this group. Clear prevalence of thrombosis was verified in group A, with 50% located in the apical lesion, whose main differential factor was a greater incidence of arrhythmias. Myopathy (heart weight above 500g) was primordial for the presence of thrombosis in both groups.

【 授权许可】

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