Human papillomavirus: prevalence and genotypes found among HIV-positive and negative women at a reference center in the far south of Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Entiauspe, Ludmila Gonçalves¹  Gonçalves, Carla Vitola¹  Hospital Universitário Dr. Miguel Corrêa Riêt Júnior, Rio Grande¹  Gonçalves, Paulo¹  Teixeira, Lisiane Ortiz¹  Martinez, Ana Maria Barral de¹  Universidade Federal do Rio Grande, Rio Grande¹  Mendoza-Sassi, Raul Andrés¹ 

关键词: Human papillomavirus;    HIV;    Cervical cancer;    Polymerase chain reaction;   

DOI  :  10.1590/S0037-86822010000300009

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: The aim of this study was detect the presence of human papillomavirus and investigate the prevalence and distribution of the HPV-6, 11, 16 and 18 genotypes among HIV-1 positive and negative women.METHODS: Samples of cervical smears from 98 women were analyzed using the nested polymerase chain reaction for the presence of HPV and using the type-specific technique for genotype detection. Genotypes were confirmed by means of restriction fragment analysis. The chi-square and Fisher tests were performed for the statistical analysis.RESULTS: HPV-DNA was observed in 66.3% of the samples analyzed: 76.4% in the HIV-positive group and 60% in the HIV-negative group (p = 0.1). Higher prevalence of viral infection due to oncogenic genotypes was observed in the HIV-positive group (65.2%) than in the HIV-negative group (28.6%), (p = 0.006), and HPV-16 was the most frequent in the two groups, followed by HPV-18.CONCLUSIONS: It is suggested that HIV-positive women present a higher likelihood of infection by oncogenic HPV genotypes, and the importance of a screening and differential diagnosis program for this group is highlighted.

【 授权许可】

Unknown