Pulmonary and cardiovascular syndrome due to hantavirus: clinical aspects of an emerging disease in southeastern Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Souza, Ricardo Luiz Moro de¹  Universidade de São Paulo, Ribeirão Preto¹  Badra, Soraya Jabur¹  Figueiredo, Luiz Tadeu Moraes¹  Campos, Gelse Mazzoni¹  Borges, Alessandra Abel¹  Universidade do Sul de Santa Catarina, Tubarão¹  Moreli, Marcos Lázaro¹  Universidade de São Paulo, Pirassununga¹  Figueiredo, Glauciane Garcia¹  Universidade Estadual Santa Cruz, Ilhéus¹ 

关键词: Hantavirus;    Hantavirosis;    Clinical diagnosis;    Epidemiology;    Emerging diseases;   

DOI  :  10.1590/S0037-86822009000300009

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Pulmonary and cardiovascular syndrome due to hantavirus is a disease caused by inhalation of aerosols from the excreta of wild rodents contaminated by viruses of the Bunyaviridae family. We studied the clinical and laboratory manifestations of 70 cases that occurred in the region of Ribeirão Preto, SP, Brazil, between 1998 and 2007. The frequency of symptoms was as follows: dyspnea (87%), fever (81%), coughing (44%), headache (34%), tachycardia (81%), low arterial blood pressure (56%), metabolic acidosis (57%), lymphocytopenia (51%), hematocrit > 45% (70%), leukocytosis with left deviation (67%), creatinine (51%) and urea (42%). Mortality (54.3%) occurred mainly on the fourth day. Respiratory insufficiency, low arterial blood pressure and shock occurred after 24 to 48 hours. High hematocrit and decreased platelet levels were signs strongly suggestive of the disease. The diagnostic hypothesis of atypical pneumonia was associated with a good prognosis (p = 0.0136). Fluid infusion greater than 2,000 ml and arterial hypotension were associated with a poor prognosis (p = 0.0286 and p = 0.0453).

【 授权许可】

Unknown