The relation between seroprevalence of antibodies against phenolic glycolipid-I among school children and leprosy endemicity in Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Klatser, Paul R.¹  Bührer-Sékula, Samira¹  Universidade Federal de Florianópolis, Florianópolis, Brasil¹  Luis, Magali Chaves¹  Faber, William R.¹  Dutra, Marco Antonio Lopes¹  Universidade Federal de Belo Horizonte, Belo Horizonte, Brasil¹  Madeira, Elisabete Santos¹  Instituto Real Tropical, Amsterdã, Holanda¹  Universidade Federal de Goiás, Goiânia, Brasil¹  Lecco, Rita¹  Secretaria de Saúde Pública do Estado do Espírito Santo, Vitória, Brasil¹  Laboratório de Referência da Secretaria de Saúde Pública, Vitória, Brasil¹  Oskam, Linda¹  van Beers, Stella¹  Universidade de Amsterdã, Amsterdã, Holanda¹ 

关键词: Leprosy;    Serology;    Epidemiology;    School children survey;   

DOI  :  10.1590/S0037-86822008000700017

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Leprosy control programs would benefit expressively from an easy method to estimate disease prevalence and to assess the effect of leprosy control measures on disease prevalence. Determination of the seroprevalence of antibodies to PGL-I through school children surveys might be a useful indicator of leprosy prevalence at the district level. To investigate whether seropositivity rates could be related to leprosy detection rates and whether seropositivity could be used as a proximal indicator to predict the leprosy incidence in other areas, 7,073 school children in three different leprosy-endemic states in Brazil were tested. The results show a widely varying distribution of seropositivity in the communities independent of the number of leprosy cases detected. Seroprevalence was significantly lower at private schools. No differences in the patterns of seropositivity between ELISA and dipstick were observed. No correlation between leprosy detection rate and seropositivity rates could be established.

【 授权许可】

Unknown