Comparative clinical and ultrasound study of egg-negative and egg-positive individuals from Schistosoma mansoni low morbidity endemic areas, and hospitalized patients with hepatosplenic disease

Revista da Sociedade Brasileira de Medicina Tropical

Gazzinelli, Andrea¹  Universidade Federal de Minas Gerais, Belo Horizonte¹  Alvarez, Maria Carolina B.¹  Silveira, Alda Maria S.¹  Correa-Oliveira, Rodrigo¹  Faculdade de Medicina do Triângulo Mineiro, Uberaba¹  Fraga, Lucia Alves Oliveira¹  School of Medicine and Biomedical Sciences, New York, USA¹  Universidade Vale do Rio Doce, Governador Valadares¹  Santa Casa Hospital de Belo Horizonte, MG, Belo Horizonte¹  Caldas, Iramaya R.¹  Magalhães, Telcia V.B.¹  LoVerde, Philip¹  Prata, Aluízio¹  Bethony, Jeffrey¹  The George Washington University Medical Center, Washington, USA¹  Gazzinelli, Giovanni¹  Silva, F.C. Lima e¹  Fundação Oswaldo Cruz, Belo Horizonte¹ 

关键词: Schistosomiasis mansoni;    Ultrasonography;    Periportal fibrosis;   

DOI  :  10.1590/S0037-86822005000100007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Two hundred and twenty three subjects from a Schistosoma mansoni low morbidity endemic area and nine hospitalized hepatosplenic patients were submitted to stool test and clinical examination and abdomen ultrasound assessments. According to stool examination and ultrasound results, they were grouped as follows: G1 - 63 Schistosoma mansoni egg-negative individuals; G2 - 141 egg-positive patients and without evidence of periportal fibrosis; G3 - 19 egg-positive patients with periportal echogenicity (3-6mm); and G4 - 9 hepatosplenic patients with periportal echogenicity (> 6mm). Hepatomegaly detected by physical examination of the abdomen evaluated in the midclavicular line was verified in G1, G2 and G3, respectively, in 11.1, 12.1 and 26.3%. In G1, G2 and G3, periportal thickening occurred only in schistosomal patients (8.5%). Mild pathological alterations in patients that cannot yet be detected by clinical examination were detectable in the liver by ultrasound and can be due to fibrosis. The degree of mild periportal fibrosis was diminished in 57.9% of patients 12 months after treatment of schistosomiasis with oxamniquine. At ultrasonography, the mean liver left lobe measurement of G3 was larger than that of G1, and that of G4 larger than that of G1 and G2. The mean size of the spleen of G4 was significantly larger than that of the other three groups, and that of G3 larger than that of G1 and G2.

【 授权许可】

Unknown