Bone marrow cells transplant in the treatment of chronic chagasic cardiomyopathy

Revista da Sociedade Brasileira de Medicina Tropical

Carvalho, Antônio Carlos Campos de¹  Universidade Federal do Rio de Janeiro¹  Fundação Oswaldo Cruz, Salvador¹  Santos, Ricardo Ribeiro dos¹  Soares, Milena Botelho Pereira¹  Ministério da Ciência e Tecnologia, Brasília¹ 

关键词: Chagas' disease;    Cardiomyopathy;    Stem cells;    Bone marrow;    Autologous transplant;   

DOI  :  10.1590/S0037-86822004000600012

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Chronic chagasic cardiomyopathy remains a major cause of death due to heart failure in Latin American countries and for which there is currently no effective treatment. While chagasic patients wait for the development of more efficient and less toxic chemotherapeutics for the elimination of Trypanosoma cruzi, a new strategy has appeared in an attempt to repair or ameliorate the damage caused to the myocardium of patients with chronic chagasic cardiomyopathy. This therapy, involving the transplant of bone marrow cells obtained from the patient to be treated, may lead to improvement in heart function and in life quality of patients with severe chagasic cardiopathy, similar to that obtained with this approach in the treatment of patients with heart failure of ischemic etiology. The possible effects of cell therapies and its applications in chronic chagasic cardiopaths are discussed in the present report.

【 授权许可】

Unknown