Evaluation of antiparasitic activity of allopurinol, against Trypanosoma cruzi, in experimental system using infected triatomines

Revista da Sociedade Brasileira de Medicina Tropical

Universidade de São Paulo, Brasil¹  Carignani, Fábio Luís¹  Amato Neto, Vicente¹  Braz, Lúcia Maria Almeida¹  Souza, Eliana Rodrigues de¹ 

关键词: Trypanosoma cruzi;    Allopurinol;    Activity in the digestive tract of triatomines;   

DOI  :  10.1590/S0037-86822000000600016

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The antiparasitic activity of allopurinol, against Trypanosoma cruzi, was evaluated by a procedure using infected triatomines. This methodology indicated that the drug was unable to eliminate the protozoa in the digestive tract of the insects. Therefore, further knowledge to improve our understanding of allopurinol in the context of the etiologic treatment of infection by T. cruzi was not acquired. Despite this finding the drug continues to be used, even though its performance appears to be full of divergences and contradictions.

【 授权许可】

Unknown