Immune response produced by rabies vaccines in marmosets (Callithrix sp)

Revista da Sociedade Brasileira de Medicina Tropical

Oliveira, Alexandre Nunes de¹  Romijn, Phyllis Catharina¹  Kimura, Leda Maria Silva¹  Andrade, Márcia Cristina Ribeiro¹  Fundação Instituto Oswaldo Cruz, Rio de Janeiro, Brasil¹ 

关键词: Rabies;    Vaccine;    Immunization;    Marmoset;    Callithrix sp;   

DOI  :  10.1590/S0037-86821999000500011

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

In order to evaluate the immune response produced by rabies vaccines in new world nonhuman primates, thirty marmosets (Callithrix sp) were divided into five groups of six individuals and submitted to five different antirabies vaccination schemes using two distinct commercially available animal vaccines. The first was produced in suckling mouse brain (Fuenzalida and Palacios), and the second in NIL-2 cell culture. Post-vaccine serological monitoring was carried out periodically. The results showed that the Fuenzalida and Palacios vaccine was not able to protect the animals when using a single dose or even with a booster. But when submitted to a vaccination routine similar to that used for humans, the marmosets showed detectable antibodies, and only one succumbed to rabies after being challenged. In addition, the vaccine produced in NIL-2 cell culture induced high antibody levels in all vaccinated animals and all animals survived the viral challenge.

【 授权许可】

Unknown