Does a spontaneous cure for chagas' disease exist?

Revista da Sociedade Brasileira de Medicina Tropical

Rezende, J. Marcondes de¹  Vargas, Luis G.¹  Universidade Federal de Minas Gerais, Brasília, Brasil¹  Dias, João Carlos P.¹  U.F., Goiânia, Brasil¹  Urbina, Andrea¹  Zeledón, Rodrigo¹  Universidad Nacional, Heredia, Costa Rica¹  Hospital México, San José, Costa Rica¹  Brilla-Salazar, A.¹ 

关键词: American trypanosomiasis;    Chagas' disease;    Spontaneous cure;    Longitudinal studies;   

DOI  :  10.1590/S0037-86821988000100003

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Six Costa Rican Chagas' disease patients, with wellknown acute phase history and no specific treatment were examined in several occasions during 39, 24, 32, 16 and 14 years, respectively, from the onset. Nome of the patients presented heart abnormalities as revealed by the conventional EKG and ergometry, exceptfor one of them with an incomplete block of the right bundle branch. Also, no alterations of the oesophagus motility was detected manometrically except for another patient who presented a slight hypersensivity reaction to a pharmacological test (Mecholyl). Three out of six patients became serologically negative in 1981, remaining as such until 1986. Besides the conventional serology, the search of protective ("lytic") antibodies was also performed in 1985 and 1986, being completely negative in one of the "cured" patients and dubious in the other two. The hypothesis that these three patients had as spontaneous cure, based on the clinical, serological and parasitologica l findings is discussed.

【 授权许可】

Unknown