Antibiotic Resistance of Community and Hospital Acquired Methicillin-Resistant Staphylococcus aureus Isolates from Clinical Specimens | Science Publications

American Medical Journal

Aza B. Taha¹  Sabria M.S. Al-Salihi¹ 

关键词: Methicillin-Resistant Staphylococcus aureus (MRSA);    antibiotic resistance;    Penicillin-Binding Protein (PBP);    nucleic acid;    clinical specimens;    soft-tissue infections;    controlling nosocomial transmission;    hospital acquired;    antibacterial agents;   

DOI  :  10.3844/amjsp.2011.65.71

学科分类：基础医学

来源: Science Publications

【 摘 要 】

Problem statement: Methicillin-Resistant Staphylococcus aureus (MRSA) is responsiblefor an increasing number of serious hospital and community acquired infections. Increased emergencein MRSA resistance to antibiotics is a growing problem. Approach: The resistance of MRSA to 20antibiotics agents were studied. Also comparison of antibiotics resistance of community and hospitalacquired MRSA were performed. Meanwhile the profile of antibiotics resistance of different clinicalspecimens among community and hospital acquired MRSA were evaluated. The clinical specimens ofwound, urine, diabetic foot, skin abscess and sputum were collected from 1189 patients from March2008-2009 at Hawler, Maternity and Rizgary teaching hospitals in Erbil, Iraq, 377 of Staphylococcusaureus were isolated and identification by standard methods, 114 MRSA were detected by detectionPBP2a. Antibiotics resistance for MRSA were determined by the agar dilution method according toCLSI and BSAC guidelines. Results: The percentages of resistance in all hospital acquired MRSAwere higher than community acquired MRSA. Among community acquired MRSA, the highestpercentage (73.33%) of wound specimens were resistance to tetracycline, erythromycin andazithromycin. About 14% of urine samples were resistance to tobramycin, levofloxacin, moxifloxacinand rifampicin, 12.5% of diabetic foot was resistance to tobramycin, moxifloxacin and rifampicin. Theresistance to tobramycin and rifampicin among MRSA cause skin abscess were 10 and 75% of sputumspecimens were resistance to azithromycin and ciprofloxacin. Among hospital acquired MRSAisolates, 92% of wound specimens were resistance to tetracycline, 85.71% of urine samples wereresistance to erythromycin and azithromycin. All sputum specimens were resistance to erythromycin.Conclusion/Recommendations: The most antibiotics affected agents MRSA were gatifloxacin,moxifloxacin and rifampicin. Physicians should be aware about MRSA and order for diagnostic andantibiotics sensitivity test. The use of antibiotics on random scale without antibiotic sensitivity testingmust be restricted.

【 授权许可】

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