Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro | Science Publications

American Journal of Immunology

Milena Menegazzo Miranda¹  Suzana Lucy Nixdorf¹  Juliana Aparecida Macri¹  Sérgio Ricardo Ambrósio¹  Thiago Hideki Hayashida¹  Waldiceu Aparecido Verri Jr¹  Tiago Bervelieri Madeira¹  Wander Rogério Pavanelli¹  Ivete Conchon-Costa¹  Nilton Syogo Arakawa¹  Natalia Yoshie Kawakami¹  Vinicius Ricardo Acquaro Junior¹  Suelen Santos da Silva¹  Rubens Cecchini¹ 

关键词: Immunomodulation;    Kaurenoic Acid;    Macrophages;    In Vitro Study;   

DOI  :  10.3844/ajisp.2014.183.188

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

Kaurenoicacid has been displaying anti-inflammatory effect described in differentmodels. However, the per se immunomodulatory effects of kaurenoic acid remainto be investigated. Thus, the immunomodulatoryand antioxidant effects of kaurenoic acid were investigated in vitro onperitoneal macrophages from BALB/c mice. Kaurenoic acid induced per se theproduction of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased thelevels of IL-10. There was also reduction of NO production and induction ofanti-oxidant profile. Therefore, in addition to inhibiting inflammation,kaurenoic acid presents immunomodulatory effects per se.

【 授权许可】

Unknown