HOW MICRORNAS AFFECT THE EXPRESSION OF HUMAN LEUKOCYTE ANTIGENG IN PREGNANCY | Science Publications

American Journal of Immunology

Cees Oudejans¹  Ayla Carmel Kempers¹  Marie Van Dijk¹ 

关键词: microRNA;    HLA-G;    Pre-Eclampsia;    miR-148;    miR-152;   

DOI  :  10.3844/ajisp.2012.136.145

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

The expression of Human Leukocyte Antigen G (HLA-G) on Fetal Extravillous Trophoblast (EVT) cells during pregnancy plays an important role in preventing the fetus from rejection by suppressing the maternal immune system. Decreased expression levels of HLA-G have already shown to be associated with several complications of pregnancy such as pre-eclampsia. However, it remains largely unknown how HLA-G gene expression is regulated with regard to its function and its complications. Polymorphisms and microRNAs affect HLA-G gene expression and the formation of isoforms. Interestingly, three microRNAs, miR-148a, miR 148b and miR-152, downregulate HLA-G expression with functional consequences. Since HLA-G expression levels are reduced in pre-eclampsia without a known cause, we hypothesize that these microRNAs are involved in the development of pre-eclampsia. This review discusses how microRNAs can affect HLA-G gene expression and its functions. Additionally, the role of microRNAs in the development of pre-eclampsia will be reviewed.

【 授权许可】

Unknown