Antiviral and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin | Science Publications

American Journal of Immunology

Kawkab Y. Saour¹  Najim A. Al-Masoudi¹  Bahjat A. Saeed¹  Rita S. Elias¹ 

关键词: Dihydropyridones;    curcumin;    ant-HIV-1;    QSAR;    logP;    AM1 Hamiltonian;   

DOI  :  10.3844/ajisp.2010.25.28

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

Problem statement: Pyridones are known to have variety of biological activities likeantitumor, antibacterial, anti-inflammatory and antimalarial activities. This study presents antiviralevaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison.Approach: The compounds evaluated for their in vitro antiviral activities against the viruses: HIV-1,Bovin viral Diarrhea, Yellow Fever, Reovirus 1, Herpesvirus 1, Vaccinia, Vescular Stomatitis,Coxackie virus B2, Poliovirus 1 and Respiratory Syncytial viruses by using Microculture Tetrazoliumassay (MTT) method. The method was based on the metabolic reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Results: Antiviral biological activities represented as CC50 werewithin the range >100-26 for BHK-21, while they were within the range >90-≥13 against RespiratorySyncytial Virus when represented as EC₅₀ for example. Both CC₅₀ and EC₅₀ values were found toincrease with increasing chain length of the substituent on the nitrogen atom. Conclusion: The in vitroantiviral activities of the tested dihydropyridones can be enhanced by increasing chain length of thesubstituent on the nitrogen atom.

【 授权许可】

Unknown