American Journal of Immunology | |
Antiviral and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin | Science Publications | |
Kawkab Y. Saour1  Najim A. Al-Masoudi1  Bahjat A. Saeed1  Rita S. Elias1  | |
关键词: Dihydropyridones; curcumin; ant-HIV-1; QSAR; logP; AM1 Hamiltonian; | |
DOI : 10.3844/ajisp.2010.25.28 | |
学科分类:过敏症与临床免疫学 | |
来源: Science Publications | |
【 摘 要 】
Problem statement: Pyridones are known to have variety of biological activities likeantitumor, antibacterial, anti-inflammatory and antimalarial activities. This study presents antiviralevaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison.Approach: The compounds evaluated for their in vitro antiviral activities against the viruses: HIV-1,Bovin viral Diarrhea, Yellow Fever, Reovirus 1, Herpesvirus 1, Vaccinia, Vescular Stomatitis,Coxackie virus B2, Poliovirus 1 and Respiratory Syncytial viruses by using Microculture Tetrazoliumassay (MTT) method. The method was based on the metabolic reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Results: Antiviral biological activities represented as CC50 werewithin the range >100-26 for BHK-21, while they were within the range >90-≥13 against RespiratorySyncytial Virus when represented as EC50 for example. Both CC50 and EC50 values were found toincrease with increasing chain length of the substituent on the nitrogen atom. Conclusion: The in vitroantiviral activities of the tested dihydropyridones can be enhanced by increasing chain length of thesubstituent on the nitrogen atom.
【 授权许可】
Unknown
【 预 览 】
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RO201912010159870ZK.pdf | 170KB | download |